AFF3 upregulation mediates tamoxifen resistance in breast cancers
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چکیده
منابع مشابه
Tamoxifen Resistance in Breast Cancer
Tamoxifen is a central component of the treatment of estrogen receptor (ER)-positive breast cancer as a partial agonist of ER. It has been clinically used for the last 30 years and is currently available as a chemopreventive agent in women with high risk for breast cancer. The most challenging issue with tamoxifen use is the development of resistance in an initially responsive breast tumor. Thi...
متن کاملDicer-mediated upregulation of BCRP confers tamoxifen resistance in human breast cancer cells.
PURPOSE Tamoxifen (Tam) is the most prescribed hormonal agent for treatment of estrogen receptor α (ERα)-positive breast cancer patients. Using microarray analysis, we observed that metastatic breast tumors resistant to Tam therapy had elevated levels of Dicer. EXPERIMENTAL DESIGN We overexpressed Dicer in ERα-positive MCF-7 human breast cancer cells and observed a concomitant increase in exp...
متن کاملCancer Therapy: Preclinical Dicer-Mediated Upregulation of BCRP Confers Tamoxifen Resistance in Human Breast Cancer Cells
Purpose: Tamoxifen (Tam) is the most prescribed hormonal agent for treatment of estrogen receptor a (ERa)-positive breast cancer patients. Using microarray analysis, we observed that metastatic breast tumors resistant to Tam therapy had elevated levels of Dicer. Experimental Design: We overexpressed Dicer in ERa-positive MCF-7 human breast cancer cells and observed a concomitant increase in exp...
متن کاملSTAT3 mediates resistance of CD44+CD24−/low breast cancer stem cells to tamoxifen in vitro
We sought to determine whether STAT3 mediated tamoxifen resistance of breast cancer stem cells in vitro. The capacities for mammosphere formation and STAT3 expression of CD44(+)CD24(-/low) MCF-7 and MCF-7 were observed. The CD44(+)CD24(-/low) subpopulation ratio and its sensitivity to adriamycin were analyzed in MCF-7 and TAM resistant (TAM-R) cells. Cell cycle, apoptosis, STAT3 and phospho-STA...
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s and Presentations: Mertz, J. E., Esch, A. M., and Burgess, R. R.. Estrogen-related Receptor Alpha Target Genes: Identification of Novel Biomarkers of Aggressive Breast Cancer. DOD-BCRP Era of Hope Conference, Orlando, FL, August, 2011. Mertz, J. E. Kraus, R. J., and Lillios, N. P. Regulation of Estrogen-related Receptor Alpha Activity by its Tyrosine at Residue 400. DOD-BCRP Era of Hope Confe...
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ژورنال
عنوان ژورنال: Journal of Experimental & Clinical Cancer Research
سال: 2018
ISSN: 1756-9966
DOI: 10.1186/s13046-018-0928-7